You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit


Publications of databases providing essential data for ActiveDriverDB:

  • Hornbeck P. V. et al., PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res. 43:D512-20 (2015). PubMed: 25514926
  • Dinkel, H. et al., Phospho.ELM: a database of phosphorylation sites--update 2011. Nucleic acids research 39, D261-267 (2011). PubMed: 21062810
  • Keshava Prasad, T. S., et al. Human Protein Reference Database--2009 update. Nucleic acids research 37, D767-772 (2009). PubMed: 18988627
  • The UniProt Consortium. UniProt: the universal protein knowledgebase Nucleic Acids Res. 45: D158-D169 (2017)   PubMed: 29425356
  • The Cancer Genome Atlas Research Network. The Cancer Genome Atlas Pan-Cancer analysis project. Nature Genetics 45, 1113-1120 (2013). PubMed: 24071849
  • Ellrott K. et al., Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. Cell Systems. Mar 28;6(3):271-281.e7 (2018). PubMed: 29596782 
  • 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68-74. (2015). PubMed: 26432245 
  • Tennessen, J. A., et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337, 64-69 (2012). PubMed: 22604720
  • Landrum, M. J., et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res 42, D980-985 (2014). PubMed: 24234437
  • The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature 578, 82–93 (2020). PubMed: 32025007
  • Bouhaddou, M., et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell, 182(3), 685-712.e19 (2020) PubMed: 32645325

We used following resources to provide external references (protein mappings):

Pathways lists are based on a gmt file retrieved from g:Profiler resource:

  • Reimand, J., et al. g:Profiler -- a web server for functional interpretation of gene lists (2016 update) Nucleic Acids Res. 44(W1) W83-9 (2016). PubMed: 27098042

Protein description summaries and full protein names (as on RefSeq pages) were retrieved using UCSC Table browser:

DrugBank (CC-BY-NC/4.0 licensed) data are used for drug kinase interaction networks.

  • Wishart D.S., et al. Drugbank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. Jan 1;34 (Database issue):D668-72 (2006) PubMed: 16381955.

The results shown here are in whole or part based upon data generated by the TCGA Research Network:

Our database uses data from the PhosphositePlus database which is not for commercial use; please see Terms and Conditions on the following page: Terms of Use and License.